Name: Mag COOH 2800 Carboxyl Magnetic Beads, Excellent Stability High Flexibility
Price: 450.00 USD

- Overview
  - Carboxyl magnetic beads are superparamagnetic microspheres functionalized with carboxyl groups on their surface. Their core characteristic lies in the versatility of the carboxyl group: it can be simply chemically activated (typically using carbodiimide catalysts like EDC/NHS) to form stable amide bonds with biological molecules (such as amines on proteins, antibodies, or nucleic acids), thereby achieving covalent coupling.
    Simply put, carboxyl magnetic beads are like a "universal magnetic platform" or a "blank canvas". Users can immobilize various "functional brushes" (biological ligands) onto them according to their specific needs, thus customizing magnetic separation tools for particular targets.
    
    Product Features
    · Strong Versatility: Can be coupled to any biological molecule containing primary amine groups, including antibodies, proteins, peptides, oligonucleotides, enzymes, etc., resulting in an extremely broad application range.
    · High Binding Capacity: Optimization of surface chemistry and particle size provides a large specific surface area, enabling high-load coupling and enhancing detection sensitivity.
    · High Coupling Efficiency: The chemical reaction is mature and efficient, and can proceed under mild aqueous conditions.
    · Excellent Stability: The covalent bond is strong; prepared capture beads can be stored long-term with stable performance.
    · Low Non-specific Adsorption: Optimized surface modification and blocking processes effectively reduce non-specific binding to non-target substances, yielding a high signal-to-noise ratio.
    · High Flexibility: Users can couple their required ligands themselves, meeting the needs of personalized research and product development.
    
    Please contact us at for specific academic pricing.
- Properties
  - Concentration
    
    10 mg/mL
    
    Other Properties
    
    Highlight: Carboxyl Magnetic Beads Excellent Stability, Mag COOH 2800 Carboxyl Beads, High Flexibility Carboxyl Magnetic Beads
    Preserver: Ultra pure water
    Validity: 24 months from date of manufacture
    Matrix: Polymers
    Particle size: 2800nm
    
    Certifications
    
    ISO 9001, ISO 13485
    
    * For research use only. Not for human or veterinary use.
- Applications
  - Application
    
    Enrichment, purification and detection of biological samples
    
    Application Description
    
    Carboxyl magnetic beads are the cornerstone of customized bio-separation technology, and their applications cover almost all magnetic separation scenarios.
    · Immunoassays and Diagnostics
    This is the largest application area. By coupling specific antibodies to carboxyl magnetic beads to create immunomagnetic beads, they are used for:
    Chemiluminescence Immunoassays: Serving as the solid-phase carrier for capture and separation, widely used in fully automated chemiluminescence immunoanalyzers to detect tumor markers, hormones, infectious disease markers, etc.
    Immunochromatography: Used as a label in fluorescent or magnetic immunochromatographic test strips to improve detection sensitivity.
    Cell Sorting: Isolating target cells (e.g., CD4+ T cells, circulating tumor cells - CTCs) from blood or tissue suspensions by coupling antibodies against specific cell surface markers. Although more specialized cell sorting beads have special coatings, the principle is based on this.
    
    · Nucleic Acid Extraction and Purification
    Although not directly involved in binding, carboxyl magnetic beads are an important precursor for preparing silanol magnetic beads. Surface chemistry can convert carboxyl groups into silanol groups used for DNA/RNA extraction. Additionally, they can be directly coupled with nucleic acid probes for capturing specific sequences.
    
    · Protein and Peptide Purification
    Affinity Purification: Coupling specific antibodies or ligands (e.g., nickel ion chelators) for tag proteins (like GST, His tags) to purify recombinant proteins.
    Co-immunoprecipitation: Coupling antibodies against a target protein to "pull down" the protein and its interaction complexes from cell lysates, studying protein-protein interactions.
    Enzyme Immobilization: Fixing enzymes onto the beads facilitates recovery and reuse after catalytic reactions.
    
    · Food Safety and Environmental Monitoring
    Rapid Pathogen Detection: Enriching and detecting trace microorganisms in food or water samples by coupling specific antibodies against pathogens like Salmonella and E. coli.
    Toxin Detection: Using competitive immunoassays by coupling antigens for small molecules like aflatoxin and ochratoxin.
    
    · Drug Screening and Targeted Therapy
    Target Fishing: Immobilizing drug target proteins on the beads to screen lead compounds from natural product libraries that can bind to them.
    Magnetic Targeted Drug Delivery: Loading drugs onto carboxyl magnetic beads and guiding them to the lesion site via an external magnetic field for targeted therapy.

Mag COOH 2800 Carboxyl Magnetic Beads, Excellent Stability High Flexibility

Mag COOH 2800 Carboxyl Magnetic Beads, Excellent Stability High Flexibility

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