m-dPEG®₈-NHS ester

m-dPEG®8-NHS ester, product number 10260, is a medium length, methyl-terminated, discrete length polyethylene glycol (dPEG®) spacer. With a reactive end as the N-hydroxysuccinimidyl (NHS) ester, m-dPEG®8-NHS ester is designed to modify surfaces containing accessible free amines. NHS reacts optimally with free amines at pH 7.2 – 7.5. The hydrolytic rate of the ester to the carboxylic acid increases with increasing pH. Please note that modification of surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Many applications employ this m-dPEG®8-NHS ester. Published papers using this product include:

imaging applications;
design of a delivery mechanism for an anti-HIV therapeutic peptide;
coating of carbon nanotubes, gold nanoshells, and silica shelled quantum dots;
PK improvement of organophosphorus hydrolase in a therapeutic application;
peptide synthesis; and,
development of antibacterial, cytotoxic dendrimers.

m-dPEG®8-NHS ester, product number 10260, is just one member of an comprehensive line of methyl-terminated dPEG® products. This line includes dPEG® spacers containing 2 to 49 ethylene glycol units. These products are functionalized with NHS or with 2,3,5,6-tetrafluorophenol (TFP). TFP has proven to be superior to NHS for amine-reactive products.

Quanta BioDesign, Ltd., makes and sells single molecular weight PEG linkers and spacers with discrete chain lengths under the trade name dPEG®. Our products are distinctly different from traditional PEG products in that they are not disperse polymers. However, they confer all of the benefits of traditional PEG products.

Please contact us at for specific academic pricing.