Lopinavir, Bio-X - Amerigo Scientific

- Overview
  - Chemically derived from ritonavir, Lopinavir belongs to the amphetamines and in a dicarboxylic acid diamide class. Lopinavir is clinically used in the prevention and treatment of HIV infections as it acts as HIV-1 protease inhibitor. In 2020, lopinavir was tested to treat COVID-19 patients and although it led to a higher rate of gastronintestinal side effects, the Lopinavir-treated group had a lower incidence of severe complications.
    
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- Properties
  - Categories
    
    Antivirals
    
    Alternative Name
    
    (α-S)-N-[(1S,3S,4S)-4-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5 -phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)- 2-oxo-1(2H)-pyrimidineacetamide;A 157378.0;ABT 378
    
    CAS Number
    
    192725-17-0
    
    Molecular Formula
    
    C37H48N4O5
    
    Molecular Weight
    
    628.8 g/mol
    
    MDL Number
    
    MFCD28988846
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Cao et al (2020). A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19. The New England Journal of Medicine, 382:1787-1799.
    Cvetkovic et al (2003). Lopinavir/ritonavir: a review of its use in the management of HIV infection. Drugs, 63:769–802.