Lomustine

- Overview
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    Background
    
    Lomustine is an antineoplastic drug used in chemotherapy [1]
    Lomustine has been revealed to inhibit the growth of tumour cell lines with IC50 values of 25μM, 8.8μM and 13μM for breast ZR-75-1, astrocytoma U87MG and colorectal LS174T cell lines [2]. Besides, Lomustine has been found to be particularly effective in the treatment of certain neoplasms of the central nervous system, because of the high lipid solubility and permeability through the blood brain barrier. In addition, Lomustine has shown the effect function in treatment of meningeal leukemia in the mouse and in children who have acute leukemia with central nervous system involvement [1].
    
    [1] Cheng CJ, Fujimura S, Grunberger D, Weinstein IB. nteraction of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC 79037) with nucleic acids and proteins in vivo and in vitro. Cancer Res. 1972 Jan;32(1):22-7.
    [2] Baer JC1, Freeman AA, Newlands ES, Watson AJ, Rafferty JA, Margison GP. Depletion of O6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells.Br J Cancer. 1993 Jun; 67(6):1299-302.
- Properties
  - Categories
    
    Antineoplastic drug
    
    Alternative Name
    
    1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
    
    CAS Number
    
    13010-47-4
    
    Molecular Formula
    
    C9H16ClN3O2
    
    Molecular Weight
    
    233.7
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; ≥23.41 mg/mL in DMSO; ≥23.9 mg/mL in EtOH
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    C1CCC(CC1)NC(=O)N(CCCl)N=O
    
    * For Research Use Only