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Overview
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Background
Lithium Citrate is the active component of Lithium which is a drug used in treatment of psychiatric disease [1].
Lithium Citrate has shown the effects on metabolic and signaling pathways in the brain based on the specific clinical condition and disease model [2]. Lithium Citrate has been reported to use as a mood stabilizer when treating bipolar mood disorders (BD) and reduce the risk of self-harm in BD patient. In addition, Lithium Citrate has been found to be the choice drug in treatment of acute manic episodes. Moreover, Lithium Citrate has been revealed to dissolve uric acid crystals in urine obtained from patients with gout. Besides, Lithium Citrate has been exhibited to have some dose-dependent side-effects. The most of the side-effects of Lithium Citrate is the tendency to inhibit the prostatic acid phosphatase enzyme (PAP), which leading to the accumulation of PAP [1].[1] Oruch R1, Elderbi MA2, Khattab HA3, Pryme IF4, Lund A5. Lithium: A review of pharmacology, clinical uses, and toxicity. Eur J Pharmacol. 2014 Jun 30. pii: S0014-2999(14)00493-2.
[2] Janson CG1, Assadi M, Francis J, Bilaniuk L, Shera D, Leone P.Lithium citrate for Canavan disease. Pediatr Neurol. 2005 Oct; 33(4):235-43.
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