Name: Liproxstatin-1
Price: 276.00 USD

- Overview
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    Background
    
    Liproxstatin-1 is a potent inhibitor of ferroptosis with IC50 value of 22 nM [1].
    Ferroptosis is an iron-dependent non-apoptotic form of cell death induced by small molecules in engineered cells overexpressing oncogenic RAS and specific tumour types [1].
    Liproxstatin-1 is a potent ferroptosis inhibitor. Liproxstatin-1 showed inhibition against ferroptosis-inducing agent (FIN) -triggered cell death. In Gpx4-/- cells, liproxstatin-1 inhibited RSL3-induced BODIPY 581/591 C11 oxidation. In primary human renal proximal tubule epithelial cells (HRPTEpiCs), liproxstatin-1 inhibited RSL3-induced cell death. Knock down Gpx4 in the immortalized human renal proximal tubule epithelial cell line (HK-2) cells made cells more sensitive to FIN [1].
    On TAM treatment of CreERT2; Gpx4fl/fl mice, liproxstatin-1 significantly extended survival time and reduced number of TUNELC cells, which suggested that liproxstatin-1 delayed ferroptosis in tubular cells. In a hepatic ischaemia/reperfusion injury model, liproxstatin-1 mitigated tissue injury induced by ischaemia/reperfusion [1].
- Properties
  - Alternative Name
    
    N-(3-chlorobenzyl)-4'H-spiro[piperidine-4,3'-quinoxalin]-2'-amine
    
    CAS Number
    
    950455-15-9
    
    Molecular Formula
    
    C19H21ClN4
    
    Molecular Weight
    
    340.85
    
    Appearance
    
    A solid
    
    Purity
    
    99.69%
    
    Solubility
    
    insoluble in H2O; ≥10.5 mg/mL in DMSO; ≥2.39 mg/mL in EtOH with gentle warming and ultrasonic
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Xiaohong Zhang, Xueshuang Xing, et al. "Ionizing radiation induces ferroptosis in granulocyte-macrophage hematopoietic progenitor cells of murine bone marrow." Int J Radiat Biol , 1-35 2020 Jan 6. PMID:31906761
    2. Nicole L. Jenkins, Simon A. James, et al. "Ferrous-glutathione coupling mediates ferroptosis and frailty in Caenorhabditis elegans." bioRxiv. 2019 March 31.

Liproxstatin-1

Liproxstatin-1

Background

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