Name: Liproxstatin-1 HCl
Price: 268.00 USD

- Overview
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    Background
    
    Liproxstatin-1 HCl is a potent inhibitor of ferroptosis with IC50 value of 22 nM [1].
    Ferroptosis is an iron-dependent non-apoptotic form of cell death induced by small molecules in engineered cells overexpressing oncogenic RAS and specific tumour types [1].
    Liproxstatin-1 HCl is a potent ferroptosis inhibitor. Liproxstatin-1 HCl showed inhibition against ferroptosis-inducing agent (FIN) -triggered cell death. In Gpx4-/- cells, Liproxstatin-1 HCl inhibited RSL3-induced BODIPY 581/591 C11 oxidation. In primary human renal proximal tubule epithelial cells (HRPTEpiCs), Liproxstatin-1 HCl inhibited RSL3-induced cell death. Knock down Gpx4 in the immortalized human renal proximal tubule epithelial cell line (HK-2) cells made cells more sensitive to FIN [1].
    On TAM treatment of CreERT2; Gpx4fl/fl mice, Liproxstatin-1 HCl significantly extended survival time and reduced number of TUNELC cells, which suggested that Liproxstatin-1 HCl delayed ferroptosis in tubular cells. In a hepatic ischaemia/reperfusion injury model, Liproxstatin-1 HCl mitigated tissue injury induced by ischaemia/reperfusion [1].
- Properties
  - Alternative Name
    
    N-(3-chlorobenzyl)-4'H-spiro[piperidine-4,3'-quinoxalin]-2'-amine hydrochloride
    
    CAS Number
    
    950455-15-9 (free base)
    
    Molecular Formula
    
    C19H22Cl2N4
    
    Molecular Weight
    
    377.31
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in EtOH; ≥18.85 mg/mL in H2O; ≥47.6 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

Liproxstatin-1 HCl

Liproxstatin-1 HCl

Background

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