Limonin

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Limonin is a chemically-induced carcinogenesis inhibitor and HIV-1 replication inhibitor.The human immunodeficiency virus (HIV) is a lentivirus that causes the acquired immunodeficiency syndrome (AIDS).When culturing the HIV-1 in human peripheral blood mononuclear cells (PBMC) and monocytes/macrophages (M/M), Limonin inhibit the HIV-1 replication in all cellular systems and inhibit HIV-1 replication with EC50 value of 60u μM in PBMC cells in a dose-dependent way [1]. In human hepatoma HepG2 cells, limonin can induced apoptosis, which was evidenced by WB analysis of some apoptosis factors [2].In the female Syrian hamsters treated with DMBA, which can cause tumor, limonin showed a 60% reduction in tumor burden. It decreased 20% tumor number and 50% tumor mass [3]. In male F344 rats treated with azoxymethane (AOM), 0.05% limonin in diet significantly reduced (65%-92% inhibition) the incidence of colonic adenocarcinoma. Thus, limonin has chemopreventive effects on chemically induced carcinogenesis [4].
    
    [1]. Battinelli L, Mengoni F, Lichtner M, et al. Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cells. Planta medica, 2003, 69(10): 910-913.
    [2]. Langeswaran K, Gowthamkumar S, Vijayaprakash S, et al. Influence of limonin on Wnt signalling molecule in HepG2 cell lines. J Nat Sci Biol Med, 2013, 4(1): 126-133.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633262/?report=reader
    [3]. Miller EG, Fanous R, Rivera-Hidalgo, et al. The effect of citrus limonoids on hamster buccal pouch carcinogenesis. Carcinogenesis, 1989, 10(8): 1535-1537.
    [4]. Tanaka T, Kohno H, Tsukio Y, et al. Citrus limonoids obacunone and limonin inhibit azoxymethane-induced colon carcinogenesis in rats. BioFactors (Oxford, England), 2000, 13(1-4): 213-8.
- Properties
  - Alternative Name
    
    Limonoic acid 3,19:16,17 dilactone; 12-(furan-3-yl)-6,6,8a,12a-tetramethyldecahydrooxireno[2,3-d]pyrano[4',3':3,3a]isobenzofuro[5,4-f]isochromene-3,8,10(1H,6H,8aH)-trione
    
    CAS Number
    
    1180-71-8
    
    Molecular Formula
    
    C26H30O8
    
    Molecular Weight
    
    470.51
    
    Appearance
    
    A solid
    
    Purity
    
    99.76%
    
    Solubility
    
    ≥23.9 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

Limonin

Background

We Also Recommend

LKB1 (AAK1 dual inhibitor)

LRRK2-IN-1

Lu AE58054 Hydrochloride