Lentiviral human SPOP sgRNA gene knockout kit

Human SPOP

Gene symbol: SPOP
Synonyms: BTBD32 TEF2
Species: HUMAN
Gene ID: 8405
Summary: This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001007226:8:5 NM_003563:7:5 NM_001007227:7:5 NM_001007228:6:5 NM_001007230:8:5 NM_001007229:7:5 NM_001370730:7:5 NM_001370731:6:5 NM_001370732:6:5