Lentiviral human SLC25A19 sgRNA gene knockout kit

Human SLC25A19

Gene symbol: SLC25A19
Synonyms: DNC MCPHA MUP1 THMD3 THMD4 TPC
Species: HUMAN
Gene ID: 60386
Summary: This gene encodes a mitochondrial protein that is a member of the solute carrier family. Although this protein was initially thought to be the mitochondrial deoxynucleotide carrier involved in the uptake of deoxynucleotides into the matrix of the mitochondria, further studies have demonstrated that this protein instead functions as the mitochondrial thiamine pyrophosphate carrier, which transports thiamine pyrophosphates into mitochondria. Mutations in this gene cause microcephaly, Amish type, a metabolic disease that results in severe congenital microcephaly, severe 2-ketoglutaric aciduria, and death within the first year. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001126121:6:4 NM_001126122:5:4 NM_021734:6:4