Lentiviral human RUNX1T1 sgRNA gene knockout kit

Human RUNX1T1

Gene symbol: RUNX1T1
Synonyms: AML1-MTG8 AML1T1 CBFA2T1 CDR ETO MTG8 ZMYND2
Species: HUMAN
Gene ID: 862
Summary: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_004349:6:6