Lentiviral human RPE65 sgRNA gene knockout kit

Human RPE65

Gene symbol: RPE65
Synonyms: BCO3 LCA2 mRPE65 p63 rd12 RP20 sRPE65
Species: HUMAN
Gene ID: 6121
Summary: The protein encoded by this gene is a component of the vitamin A visual cycle of the retina which supplies the 11-cis retinal chromophore of the photoreceptors opsin visual pigments. It is a member of the carotenoid cleavage oxygenase superfamily. All members of this superfamily are non-heme iron oxygenases with a seven-bladed propeller fold and oxidatively cleave carotenoid carbon:carbon double bonds. However, the protein encoded by this gene has acquired a divergent function that involves the concerted O-alkyl ester cleavage of its all-trans retinyl ester substrate and all-trans to 11-cis double bond isomerization of the retinyl moiety. As such, it performs the essential enzymatic isomerization step in the synthesis of 11-cis retinal. Mutations in this gene are associated with early-onset severe blinding disorders such as Leber congenital. [provided by RefSeq, Oct 2017].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_000329:3:3