Lentiviral human ROR1 sgRNA gene knockout kit

Human ROR1

Gene symbol: ROR1
Synonyms: dJ537F10.1 NTRKR1
Species: HUMAN
Gene ID: 4919
Summary: This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_005012:3:3 NM_001083592:3:3