Lentiviral human RNF43 sgRNA gene knockout kit

Human RNF43

Gene symbol: RNF43
Synonyms: RNF124 SSPCS URCC
Species: HUMAN
Gene ID: 54894
Summary: The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_017763:9:8 NM_001305544:9:8 NM_001305545:8:6