Lentiviral human RNF213 sgRNA gene knockout kit

Human RNF213

Gene symbol: RNF213
Synonyms: ALO17 C17orf27 KIAA1618 MYMY2 MYSTR NET57
Species: HUMAN
Gene ID: 57674
Summary: This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein also contains an AAA domain, which is associated with ATPase activity. This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_020954:9:8 NM_001256071:9:8