Lentiviral human RNASEH2A sgRNA gene knockout kit

Human RNASEH2A

Gene symbol: RNASEH2A
Synonyms: AGS4 JUNB RNASEHI RNHIA RNHL THSD8
Species: HUMAN
Gene ID: 10535
Summary: The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_006397:3:3