Lentiviral human RIN2 sgRNA gene knockout kit

Human RIN2

Gene symbol: RIN2
Synonyms: MACS RASSF4
Species: HUMAN
Gene ID: 54453
Summary: The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by this gene binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family. Mutations in this gene cause macrocephaly alopecia cutis laxa and scoliosis (MACS) syndrome, an elastic tissue disorder, as well as the related connective tissue disorder, RIN2 syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001242581:8:8 NM_018993:7:7