Lentiviral human REST sgRNA gene knockout kit

Human REST

Gene symbol: REST
Synonyms: DFNA27 GINGF5 HGF5 NRSF WT6 XBR
Species: HUMAN
Gene ID: 5978
Summary: This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2018].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_005612:2:1 NM_001193508:2:1 NM_001363453:2:1