Lentiviral human RASGRP1 sgRNA gene knockout kit

Human RASGRP1

Gene symbol: RASGRP1
Synonyms: CALDAG-GEFI CALDAG-GEFII IMD64 RASGRP
Species: HUMAN
Gene ID: 10125
Summary: This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_005739:9:9 NM_001128602:9:9 NM_001306086:9:9