Lentiviral human RASA1 sgRNA gene knockout kit

Human RASA1

Gene symbol: RASA1
Synonyms: CM-AVM CMAVM CMAVM1 GAP p120 p120GAP p120RASGAP PKWS RASA RASGAP
Species: HUMAN
Gene ID: 5921
Summary: The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_002890:3:3 NM_022650:3:3