Lentiviral human RAPGEF2 sgRNA gene knockout kit

Human RAPGEF2

Gene symbol: RAPGEF2
Synonyms: CNrasGEF nRap GEP NRAPGEP PDZ-GEF1 PDZGEF1 RA-GEF RA-GEF-1 RAGEF Rap-GEP
Species: HUMAN
Gene ID: 9693
Summary: Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001351724:9:9 NM_001351725:6:5 NM_001351726:6:5 NM_001351727:3:3 NM_001351728:3:3 NM_014247:3:3