Lentiviral human LPIN1 sgRNA gene knockout kit

Human LPIN1

Gene symbol: LPIN1
Synonyms: PAP1
Species: HUMAN
Gene ID: 23175
Summary: This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, acute recurrent rhabdomyolysis, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. [provided by RefSeq, Mar 2017].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_145693:7:6 NM_001261427:8:7 NM_001261428:9:9 NM_001349199:8:6 NM_001349200:8:6 NM_001349201:7:6 NM_001349202:9:7 NM_001349203:8:7 NM_001349204:9:7 NM_001349205:9:7 NM_001349206:8:7 NM_001349207:8:8 NM_001349208:8:8