Lentiviral human ITPR2 sgRNA gene knockout kit

Human ITPR2

Gene symbol: ITPR2
Synonyms: ANHD CFAP48 INSP3R2 IP3R2
Species: HUMAN
Gene ID: 3709
Summary: The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_002223:22:22