Lentiviral human ITCH sgRNA gene knockout kit

Human ITCH

Gene symbol: ITCH
Synonyms: ADMFD AIF4 AIP4 NAPP1
Species: HUMAN
Gene ID: 83737
Summary: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001257137:15:13 NM_031483:14:12 NM_001257138:13:10 NM_001324197:15:13 NM_001324198:14:12