Lentiviral human INSR sgRNA gene knockout kit

Human INSR

Gene symbol: INSR
Synonyms: CD220 HHF5
Species: HUMAN
Gene ID: 3643
Summary: This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_000208:2:2