Lentiviral human INS sgRNA gene knockout kit

Human INS

Gene symbol: INS
Synonyms: IDDM IDDM1 IDDM2 ILPR IRDN MODY10
Species: HUMAN
Gene ID: 3630
Summary: This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2019].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_000207:2:1 NM_001185097:2:1 NM_001185098:1:1 NM_001291897:2:1