Lentiviral human IL17RC sgRNA gene knockout kit

Human IL17RC

Gene symbol: IL17RC
Synonyms: CANDF9 IL17-RL IL17RL
Species: HUMAN
Gene ID: 84818
Summary: This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_153460:3:3 NM_153461:3:3 NM_032732:3:3 NM_001203263:3:3 NM_001203264:3:3 NM_001203265:3:3 NM_001367278:3:3 NM_001367279:3:3 NM_001367280:3:3