Lentiviral human IKZF1 sgRNA gene knockout kit

Human IKZF1

Gene symbol: IKZF1
Synonyms: CVID13 Hs.54452 IK1 IKAROS LyF-1 LYF1 PPP1R92 PRO0758 ZNFN1A1
Species: HUMAN
Gene ID: 10320
Summary: This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001291844:2:2 NM_006060:3:2 NM_001220765:3:2 NM_001220767:2:2 NM_001220768:2:2 NM_001220770:2:2 NM_001220771:2:2 NM_001291837:3:2 NM_001291838:3:2 NM_001291839:3:2 NM_001291840:2:2 NM_001291841:2:2 NM_001291842:2:2 NM_001291843:2:2 NM_001291845:3:2 NM_001291846:3:2 NM_001291847:3:2