Lentiviral human HLA-DPA1 sgRNA gene knockout kit

Human HLA-DPA1

Gene symbol: HLA-DPA1
Synonyms: DP(W3) DP(W4) DPA1 HLA-DP1A HLA-DPB1 HLADP HLASB PLT1
Species: HUMAN
Gene ID: 3113
Summary: HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_033554:2:2 NM_001242524:3:2 NM_001242525:3:2