Lentiviral human HIF1A sgRNA gene knockout kit

Human HIF1A

Gene symbol: HIF1A
Synonyms: bHLHe78 HIF-1-alpha HIF-1A HIF-1alpha HIF1 HIF1-ALPHA MOP1 PASD8
Species: HUMAN
Gene ID: 3091
Summary: This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001530:9:9 NM_181054:9:9 NM_001243084:9:9