Lentiviral human GRM1 sgRNA gene knockout kit

Human GRM1

Gene symbol: GRM1
Synonyms: GPRC1A MGLU1 MGLUR1 PPP1R85 SCA44 SCAR13
Species: HUMAN
Gene ID: 2911
Summary: This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001278064:1:1