Lentiviral human GRIN2A sgRNA gene knockout kit

Human GRIN2A

Gene symbol: GRIN2A
Synonyms: EPND FESD GluN2A LKS NMDAR2A NR2A
Species: HUMAN
Gene ID: 2903
Summary: This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001134407:2:1 NM_000833:3:1 NM_001134408:2:1