Lentiviral human GPT2 sgRNA gene knockout kit

Human GPT2

Gene symbol: GPT2
Synonyms: ALT2 GPT 2 MRT49
Species: HUMAN
Gene ID: 84706
Summary: This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_133443:6:5