Lentiviral human GP1BA sgRNA gene knockout kit

Human GP1BA

Gene symbol: GP1BA
Synonyms: BDPLT1 BDPLT3 BSS CD42B CD42b-alpha DBPLT3 GP1B GPIbA GPIbalpha VWDP
Species: HUMAN
Gene ID: 2811
Summary: Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. [provided by RefSeq, Oct 2013].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_000173:2:1