Lentiviral human GNE sgRNA gene knockout kit

Human GNE

Gene symbol: GNE
Synonyms: DMRV GLCNE IBM2 NM Uae1
Species: HUMAN
Gene ID: 10020
Summary: The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001128227:5:5 NM_005476:5:4 NM_001374797:4:3 NM_001374798:4:3 NM_001190383:5:4 NM_001190384:3:2 NM_001190388:4:3