Lentiviral human FLNA sgRNA gene knockout kit

Human FLNA

Gene symbol: FLNA
Synonyms: ABP-280 ABPX CSBS CVD1 FGS2 FLN FLN-A FLN1 FMD MNS NHBP OPD OPD1 OPD2 XLVD XMVD
Species: HUMAN
Gene ID: 2316
Summary: The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001456:23:22 NM_001110556:23:22