Lentiviral human FBN1 sgRNA gene knockout kit

Human FBN1

Gene symbol: FBN1
Synonyms: ACMICD ECTOL1 FBN GPHYSD2 MASS MFLS MFS1 OCTD SGS SSKS WMS WMS2
Species: HUMAN
Gene ID: 2200
Summary: This gene encodes a member of the fibrillin family of proteins. The encoded preproprotein is proteolytically processed to generate two proteins including the extracellular matrix component fibrillin-1 and the protein hormone asprosin. Fibrillin-1 is an extracellular matrix glycoprotein that serves as a structural component of calcium-binding microfibrils. These microfibrils provide force-bearing structural support in elastic and nonelastic connective tissue throughout the body. Asprosin, secreted by white adipose tissue, has been shown to regulate glucose homeostasis. Mutations in this gene are associated with Marfan syndrome and the related MASS phenotype, as well as ectopia lentis syndrome, Weill-Marchesani syndrome, Shprintzen-Goldberg syndrome and neonatal progeroid syndrome. [provided by RefSeq, Apr 2016].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_000138:11:10