Lentiviral human ESR2 sgRNA gene knockout kit

Human ESR2

Gene symbol: ESR2
Synonyms: ER-BETA Erb ESR-BETA ESRB ESTRB NR3A2 ODG8
Species: HUMAN
Gene ID: 2100
Summary: This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001040275:2:1 NM_001291723:2:1 NM_001291712:7:1 NM_001214902:1:1 NM_001437:2:1 NM_001271877:1:1 NM_001271876:1:1