Lentiviral human EPHB2 sgRNA gene knockout kit

Human EPHB2

Gene symbol: EPHB2
Synonyms: BDPLT22 CAPB DRT EK5 EPHT3 ERK Hek5 PCBC Tyro5
Species: HUMAN
Gene ID: 2048
Summary: This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_017449:3:3 NM_004442:3:3 NM_001309192:3:3 NM_001309193:3:3