Lentiviral human EIF6 sgRNA gene knockout kit

Human EIF6

Gene symbol: EIF6
Synonyms: b(2)gcn CAB eIF-6 EIF3A ITGB4BP p27(BBP) p27BBP
Species: HUMAN
Gene ID: 3692
Summary: Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_002212:5:4 NM_181468:4:4 NM_181466:3:2 NM_001267810:5:4