Lentiviral human EIF4G1 sgRNA gene knockout kit

Human EIF4G1

Gene symbol: EIF4G1
Synonyms: EIF-4G1 EIF4F EIF4G EIF4GI P220 PARK18
Species: HUMAN
Gene ID: 1981
Summary: The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_182917:9:8 NM_198241:10:8 NM_198242:6:4 NM_198244:7:6 NM_001194946:11:9 NM_001194947:10:9 NM_001291157:10:7 NM_004953:3:3