Lentiviral human EDN3 sgRNA gene knockout kit

Human EDN3

Gene symbol: EDN3
Synonyms: ET-3 ET3 HSCR4 PPET3 WS4B
Species: HUMAN
Gene ID: 1908
Summary: The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_207032:2:2 NM_207033:2:2 NM_207034:2:2 NM_001302455:2:2 NM_001302456:2:2