Lentiviral human DUOX1 sgRNA gene knockout kit

Human DUOX1

Gene symbol: DUOX1
Synonyms: LNOX1 NOXEF1 THOX1
Species: HUMAN
Gene ID: 53905
Summary: The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_017434:5:3 NM_175940:4:3