Lentiviral human DSC3 sgRNA gene knockout kit

Human DSC3

Gene symbol: DSC3
Synonyms: CDHF3 DSC DSC1 DSC2 DSC4 HT-CP
Species: HUMAN
Gene ID: 1825
Summary: The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001941:10:10 NM_024423:10:10