Lentiviral human DPM1 sgRNA gene knockout kit

Human DPM1

Gene symbol: DPM1
Synonyms: CDGIE MPDS
Species: HUMAN
Gene ID: 8813
Summary: Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001317034:1:1