Lentiviral human DNMT3B sgRNA gene knockout kit

Human DNMT3B

Gene symbol: DNMT3B
Synonyms: ICF ICF1 M.HsaIIIB
Species: HUMAN
Gene ID: 1789
Summary: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_006892:6:5 NM_175848:6:5 NM_175849:6:5 NM_175850:6:6 NM_001207055:5:4 NM_001207056:4:3