Lentiviral human DMTF1 sgRNA gene knockout kit

Human DMTF1

Gene symbol: DMTF1
Synonyms: DMP1 DMTF hDMP1 MRUL
Species: HUMAN
Gene ID: 9988
Summary: This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_021145:13:9 NM_001142327:11:9 NM_001142326:10:7