Lentiviral human DDB2 sgRNA gene knockout kit

Human DDB2

Gene symbol: DDB2
Synonyms: DDBB UV-DDB2 XPE
Species: HUMAN
Gene ID: 1643
Summary: This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001300734:3:3 NM_000107:3:3