Lentiviral human CTLA4 sgRNA gene knockout kit

Human CTLA4

Gene symbol: CTLA4
Synonyms: ALPS5 CD CD152 CELIAC3 CTLA-4 GRD4 GSE IDDM12
Species: HUMAN
Gene ID: 1493
Summary: This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_005214:2:2 NM_001037631:2:2