Lentiviral human COX7A2L sgRNA gene knockout kit

Human COX7A2L

Gene symbol: COX7A2L
Synonyms: COX7AR COX7RP EB1 SIG81
Species: HUMAN
Gene ID: 9167
Summary: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_004718:2:2 NM_001319036:3:2 NM_001319037:2:2 NM_001319038:2:2 NM_001319040:2:2